Single-Round Infectious Particle Antiviral Screening Assays for the Japanese Encephalitis Virus

Single-Round Infectious Particle Antiviral Screening Assays for the Japanese Encephalitis Virus

Japanese Encephalitis virus (JEV) is a mosquito-borne flavivirus with a positive-sense single-stranded RNA genome that contains a big open reading frame (ORF) flanked by 5'- and 3'- untranslated regions (UTRs). Nearly 30,000 JE cases with 10,000 deaths are still annually reported in East Asia. Although the JEV genotype III vaccine has been licensed, it elicits a lower protection against other g...

Mx Is Not Responsible for the Antiviral Activity of Interferon-α against Japanese Encephalitis Virus

Mx proteins are interferon (IFN)-induced dynamin-like GTPases that are present in all vertebrates and inhibit the replication of myriad viruses. However, the role Mx proteins play in IFN-mediated suppression of Japanese encephalitis virus (JEV) infection is unknown. In this study, we set out to investigate the effects of Mx1 and Mx2 expression on the interferon-α (IFNα) restriction of JEV repli...

Global Scenario of Antiviral Drugs for Japanese Encephalitis

Japanese encephalitis a mosquito transmitted viral disease is a global confront for public health. The disease is a pediatri problem, the seriousness of the disease can be predicted as it mostly affects the children and the survivor are left with ser long term neuropsychiatric problems. Hence the disease is affecting our future generation. The only available option to control JE is vaccination ...

Neuropathogenesis of Japanese encephalitis virus.

In the central nervous system, the Japanese encephalitis virus can replicate only in neurons. The mechanism of the type of neurotropism was analyzed. The susceptibility to Japanese encephalitis virus infection in the rat brain was closely associated with neuronal immaturity. The initial specific binding of the virus to cells is one of the reasons for neurotropism of the Japanese encephalitis vi...

Immunobiology of Japanese Encephalitis Virus